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The 11st Naito Conference

Structural Genomics: Passage to Drug Development

Period 1999/10/13 (Wed.) - 1999/10/16 (Sat.)
Venue Shonan Village Center( Kanagawa-pref.)
Participants Lectures:25


Yoshimasa Kyogoku Fukui Institute of Technology
Hiroshi Hirota(Secretary) RIKEN(The Institute of Physical and Chemical Research)
Yoshihide Hayashizaki RIKEN(The Institute of Physical and Chemical Research)
Kunio Miki Kyoto University
Kosuke Morikawa Biomolecular Engineering Research Institute
Haruki Nakamura Osaka University
Yoshifumi Nishimura Yokohama City University
Makoto M. Takeo The University of Tokyo
Shigeuki Yokoyama The University of Tokyo
RIKEN(The Institute of Physical and Chemical Research)
Akiyoshi Wada RIKEN(The Institute of Physical and Chemical Research)


From Genome to Structure

  1. Structural Genomics - Mapping the Protein
    [Chris Sander]
    Millennium Predictive Medicine, USA
  2. Structural Genimics of a Hyperthermophile: a Pilot Test
    [Sung-Hou Kim]
    Dept. of Chemistry and Lawrence Berkeley Natonal Laboratory, University of California, Berkeley, USA
  3. Structural and Functional Genomics of Extreme Thermorphile
    [Seiki Kuramitsu]
    Dept. of Biology, Graduate School of Science, Osaka University, Japan
  4. Automated Analysis of Protein NMR Spectra: Prognosis for Structural and Functional Genomics
    [Gaetano T. Montelione]
    Molecular Biology and Biochemistry Center for Advanced Biotechnology and Medicine, Rutgers University, USA
  5. 3D Modeling and the Applications
    [Haruki Nakamura]
    Research Center for Structural Biology, Institute for Protein Research, Osaka University, Japan

Functional Genomic

  1. Mouse Genome Encyclopedia
    [Yoshihide Hayashizaki]
    Genomic Sciences Laboratory, RIKEN Tsukuba Life Science Center, Japan
  2. Whole Genome analysis
    [Joseph DeRisi]
    Dept. of Biochemistry and Biophysics, University of California, San Francisco, USA
  3. Using Expression Profiles to Follow Target Activities and Enable
    [Stephen H. Friend]
    Rosetta Inpharmatics, USA
  4. Saturation Gene Trapping, Functional Genomics, and Drug Target Validation
    [Authur T. Sands]
    Lexicon Genetics Incorporated, USA

Structural Biology of Infectious Agents

  1. Crystallographic Study of HIV gp120: Viral Evasion Mechanism of the Immune Response
    [Wayne A. Hendrickson]
    Dept. of Biochemistry & Molecular Biophysics, College of Physician & Surgeons of Columbia University, USA
  2. New Drugs for Influenza - an Example of Drug Design Against a Moving Target
    [Peter M. Colman]
    Biomolecular Research Institute, Australia
  3. Crystallographic Study of HIV Reverse Transcriptase towards Drug Design
    [David Stuart]
    Laboratory of Molecular Biophysics, Oxford University, UK
  4. New NMR Techniques for Studies of Prion Proteins
    [Kurt Wuthrich]
    Institute for Molecularbiology and Biophysics, ETH, Switzerland

Proteins that Bind DNA

  1. Crystal Structures of Human Topoisomerase 1 DNA Complexes and a Proposed Binding Mode of the Anti-Cancer Drug Camptothecin
    [Matthew R. Redinbo]
    Dept. of Chemistry, University of North Carolina, USA
  2. Orphan Nuclear Receptors in Drug Discovery
    [Steven A. Kliewer]
    Dept. of Molecular Endocrinology, Glaxo Wellcome Research and Development, USA
  3. Structural Biology of DNA Homologous Recombination
    [Kosuke Morikawa]
    Dept. of Structural Biology, Biomolecular Engineering Research Institute, Japan
  4. Helix-turn-helix Variants in Telomeric Proteins and Transcription Factors
    [Yoshifumi Nishimura]
    Graduate School of Integrated Scinence, Yokohama City University, Japan

COX-2 Inhibitors as Examples

  1. Strucrural and Functional Apploaches to the Development of Novel COX-2 Inhibitors
    [Lawrence J. Marnett]
    Dept. of Biochemistry and Chemistry, Center in Molecular Toxicology, and The Vanderbilt-Ingram Cancer Center, Vanderbil University School of Medicine, USA
  2. The Structural Basis for Selectivity of COX-2 Inhibitors
    [Michelle F. Browner]
    Molecular Structure Department, Roche Bioscience, USA
  3. COX-2 Inhibitors and Colon Tumorigenesis
    [Makoto Mark Taketo]
    Laboratory of Biomedical Genetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan
  4. Prostanoid Receptor Genes Knockout Mice
    [Shu Narumiya]
    Dept. of Pharmacology, Kyoto University Faculty of Medicine, Japan

G Protein - Coupled Receptors

  1. Discovery of Ligands for Orphan G Protein-coupled Receptors: Prolactin-releasing Peptide and Apelin
    [Haruo Onda]
    Discovery Research Laboratories 1, Pharmaceutical Discovery Division, Takeda Chemical Industries, Ltd., Japan
  2. Discovery and Function of Orexins and Orexin Receptors
    [Masashi Yanagisawa]
    Howard Hughes Medical Institute and Department of Molecular Genetics,University of Texas Southwestern Medical Center, USA
  3. Crystallographic Study of a Trimeric G-protein
    [Paul B. Sigler]
    Dept. of Molecular Biophysics and Biochemistry, Yale Unieversity, USA
  4. Cell Signaling Mechanisms Involving Ras-family Proteins
    [Shigeyuki Yokoyama]
    The Unversity of Tokyo, RIKEN, Wako, Japan