第13回 内藤コンファレンス

難病の分子生物学 [II]

組織委員

セッション

Plenary Lecture

1. Structural Biology of Prion Proteins

   [Kurt Wuthrich]

   Institute for Moleculabiology and Biophysics, ETH, Switzerland

SessionA
Breakdown of Tolerance and Autoantibody Production

1. Helper Requirements for Breaking CD8 T Cell Tolerance to Pancreatic Islet Antigens

   [William R. Heath]

   Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Australia

2. Peripheral Tolerance in CD8 T CElls

   [Brigitta Stockinger]

   Division of Molecular Immunology, National Institute for Medical Research, UK

3. Peripheral Tolerance to a Systemic Nuclear Autoantigen is Accomplished Through Deletion and Agergy of CD4+ T Cells by Dendritic Cells Which Present Endogeneous Nuclear Proteins

   [Kazuhiko Yamamoto]

   Department of Allegy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Japan

4. Dissection of Systemic Autoimmunnity Using TCR Transgenic Mice

   [Joseph E. Craft]

   Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, USA

5. Mechanism of Autoantibody Production

   [Tsuneyo Mimori]

   Department of Internal medicine, School of Mediine, Keio University, Japan

SessionB
Immunoreglation and Autoimmune Disorders

1. Engineering Autoimmunity

   [Diane Mathis]

   Joslin Diabetes Center, Harvard Medical School, USA

2. The CD44 Adhesion Pathway in Immunity and Autoimmunity

   [Mark H. Siegelman]

   Lab. Molecular Pathology, Dep. Pathology, The University of Texas Southwestern Medical Center, USA

3. CD40-CD154 Interactions Control Cell-mediated Immunity

   [Randolph J. Noelle]

   Department of Microbiology, Dartmouth Medical School, USA

4. Proteoglycans and their Immunomodulatory Roles - Binding to Adhesion Molecules and Chemokines

   [Masayuki Miyasaka]

   Department of Bioregulation, Biomedical Research Center, Osaka University, Graduate School of Medicine, Japan

5. Role of β1 Integrin Molecule in Cell Adhesion and Inflammation

   [Chikao Morimoto]

   Department of Clinical Immunology and AIDS Research Center, Institute of Medical Science, The University of Tokyo, Japan

SessionC
Molecular Targets on Treatment of Intractable Diseases (I)

1. Hypernuclear Acetylation in Atherosclerotic Vascular Smooth Muscle Cells

   [Toshihiro Nakajima]

   Institute of Applied Biochemistry, University of Tsukuba, Japan

2. Transcriptional Control by Nuclear Steroid Hormone Receptors

   [Shigeaki Kato]

   Institute of Molecular and Cellular Biosciences, The University of Tokyo, Japan

3. The Role of Protein Kinase C Activatin and Diabetic Vascular Complications

   [George L. King]

   Joslin Diabetes Center, Harvard Medical School, USA

4. Pathogenic Role of IL-6 and the Therapeutic Application of IL-6 Blockade to Immune-Inflammatory Diseases

   [Kazuyuki Yoshizaki]

   School of Health and Sport Sciences, Osaka University, Japan

5. Inhibition of TNFα Markedly Improves Rheumatoid Arthritis: What Does It Teach Us?

   [Marc Feldmann]

   Kennedy Institute of Rheumatology, UK

SessionD
Approach to Pathogenesis-related Genes in Rheumatic Diseases

1. Mapping the Susceptibility Genes for Human SLE

   [Timothy W. Behrens]

   Center for Immunology, University of Minnesota, USA

2. Genetic Linkages with Lupus in Americans of African and European Ancestry

   [John B. Harley]

   Oklahoma Medical Research Foundation, University of Oklahoma, USA

3. A Search for the Susceptibility Genes to Rheumatic Diseases through the Candidate Gene Approach

   [Naoyuki Tsuchiya]

   Department of Human Genetics, The University of Tokyo, Japan

4. Studies on the Disease Susceptibiligy Genes of Rheumatoid Arthritis

   [Shunichi Shiozawa]

   Department of Medicine and Molecular Genetics, Kobe University, Japan

5. Genetic Basis of RA-like Autoimmunie Arthritis in the SKG Strain of Mice

   [Shimon Sakaguchi]

   Department of Experimental Pathology, Kyoto University, Japan

SessionE
Molecular Targets on Treatment of Intractable Diseases (2)

1. Matrix Metalloproteinases and Related Metalloproteinases in Cartilage Destructin of Rheumatic Diseases

   [Yasunori Okada]

   Department of Pathology, School of Medicine, Keio University, Japan

2. Mucosal Tolerance for the Treatment of Neurologic and Other Diseases

   [Howard L. Weiner]

   Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, USA

3. Molecular Mechanism of Oral Tolerance

   [Shuichi Kaminogawa]

   Department of Applied Biological Chemistry, The University of Tokyo, Japan

4. Polyglutamine Diseases and Transcription Factors

   [Hitoshi Okazawa]

   Department of Neurology, Graduate School of Medicine, The University of Tokyo, Japan

5. Pathogenic Role and Molecular Structure of Proteins with an Expanded Polyglutamine Tract

   [Erich E. Wanker]

   Max Planck Institute for Molecular Genetics, Germany