コンファレンス

第31回 内藤コンファレンス

糖鎖の発現と制御 [II] 代謝物、ストレス応答、マイクロドメインと展望

開催期間 2011年09月13日(火)~2011年09月16日(金)
場所 シャトレーゼ ガトーキングダム サッポロ(北海道札幌市)
参加人数 招待講演者:25名
ポスター発表者:60名

組織委員

Akemi Suzuki Institute of Glycoscience. Tokai University. Japan
Jin-ichi Inokuchi Division of Glycopathology. Institute of Molecular Biomembranes and Glycobiology. Tohoku Pharmaceutical / University. Japan
Ken Kitajima Bioscience and Biotechnology Center. Nagoya University. Japan
Yasunori Kozutsumi Laboratory of Membrane Biochemistry and Biophysics. Graduate School of Biostudies. Kyoto University. Japan
Naoyuki Taniguchi Systems Glycobiology Research Group. RIKEN Advanced Science Institute and Disease Glycoprobe Team. RIKEN Max Plank Joint Center. Japan

セッション

Plenary Lecture 1

  1. Structure and function of lipids in membrane proteins
    [Tomitake TSUKIHARA]
    Department of Life Science, University of Hyogo, Japan

Session1
Plenary Lecture 2

  1. Post-translational glycosylation: Challenges and opportunities
    [Chi-HueyWONG]
    Academia Sinica, Taiwan

SessionA
Revisit to glycan metabolism

  1. Sialometabolome in health and disease
    [Ken KITAJIMA]
    Bioscience and Biotechnology Center, Nagoya University, Japan
  2. Distinct functional roles between ganglioside sialidases Neu3 and Neu4
    [Taeko MIYAGI]
    Division of Cancer Glycosylation Research, Tohoku Pharmaceutical University, Japan
  3. Development of new enzyme replacement therapy for Fabry disease based on molecular designing
    [Hitoshi SAKURABA]
    Departments of Analytical Biochemistry and Clinical Genetics, Meiji Pharmaceutical University, Japan
  4. Functional roles of O-GlcNAc modification
    [JinWon CHO]
    Department of Integrated OMICS for Biomedical Science,Yonsei University, Korea
  5. Using automated oligosaccharide synthesis to elucidate the basis of infectious disease mechanisms
    [Peter H. SEEBERGER]
    Max Planck Institute of Colloids and Interfaces and Free University, Germany and The Burnham Institute, USA
  6. Novel strategy for dynamic tracing of UDP-GlcNAc metabolism-Involvement of nucleotide sugars in glucose metabolism disorders
    [Kazuki NAKAJIMA]
    Systems Glycobiology Research Group, RIKEN Advanced Science Institute, Japan
  7. Sulfation patterns of chondroitin sulfate proteoglycans regulate critical period plasticity in the visual cortex
    [Shinji MIYATA]
    Department of Biochemistry, Kobe Pharmaceutical University, Japan

SessionB
Glycans in stress response

  1. Posttranslational glycosylation: A mechanism to enhance glycoprotein quality control
    [Reid GILMORE]
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, USA
  2. Role of autophagy in the catabolism of sialylated oligosaccharides in mammalian cells
    [Tadashi SUZUKI]
    Glycometabolome Team, RIKEN Advanced Science Institute, Japan
  3. Lectins and enzymes that regulate the mammalian glycoprotein quality control
    [Nobuko HOSOKAWA]
    Institute for Frontier Medical Sciences, Kyoto University, Japan
  4. Involvement of sphingolipids in phosphorylation and degradation ofYpk1 in the stress response of yeast
    [Yasunori KOZUTSUMI]
    Laboratory of Membrane Biochemistry and Biophysics, Graduate School of Biostudies, Kyoto University, Japan
  5. Siglec-dependent cross-talk between the innate and adaptive immune systems
    [Paul R. CROCKER]
    Division of Cell Signalling and Immunology, College of Life Sciences, University of Dundee, UK
  6. Hypoxia-induced Sialyl-Tn carbohydrate antigen expression facilitates tumor metastasis
    [Kazuaki OHTSUBO]
    Systems Glycobiology Research Group, RIKEN Advanced Science Institute, Japan
  7. Induction of autophagy by chitobiose and its derivatives
    [Hisashi ASHIDA]
    Graduate School of Biostudies, Kyoto University, Japan

SessionC
Dynamics of membrane microdomains and its physiopathological implications

  1. Membrane microdomain ortho-signaling therapy
    [Jin-ichi INOKUCHI]
    Division of Glycopathology, Institute of Molecular Biomembranes and Glycobiology, Tohoku Pharmaceutical University, Japan
  2. The lipid phase problem and the induction of a lipidosis in the endolysosomal system
    [Konrad SANDHOFF]
    LIMES co Kekulé-Institut, University of Bonn, Germany
  3. Plasma membrane glycohydrolases and new strategies for medical diagnosis and therapeutic treatments
    [Sandro SONNINO]
    Department of Chemistry, Biochemistry, and Biotechnologies for Medical Sciences, University of Milan, Italy
  4. Role of glycolipids in innate immune responses of phagocytes
    [Kazuhisa IWABUCHI]
    Infection Control Nursing, Graduate School of Health Care and Nursing, Juntendo University, Japan
  5. Ganglioside-induced conformational change of amyloid β-protein as an initial step in the process of Alzheimer disease
    [KatsuhikoYANAGISAWA]
    Research Institute, National Center for Geriatrics and Gerontology, Japan
  6. Negative regulation of LPS signals by globo-series glycosphingolipids
    [Yuji KONDO]
    Department of Biochemistry II, Nagoya University School of Medicine, Japan
  7. A new EMARS system using HRP expressed by gene manipulation technology
    [ArisaYAMAGUCHI]
    Kochi System Glycobiology Center, Kochi University Medical School, Japan

SessionD
New approaches to glycobiology

  1. Galectin-binding to specific glycoforms of serum glycoproteins: Mechanisms of selectivity, functional consequences, and relationships to disease.
    [Hakon LEFFLER]
    Section MIG (Microbiology, Immunology, Glycobiology), Department Laboratory Medicine, Lund University, Sweden
  2. Structural glycobiology approach: A glimpse into the recognition event of glycan-binding protein
    [YoshikiYAMAGUCHI]
    Chemical Biology Department, RIKEN Advanced Science Institute, Japan
  3. Structural and molecular basis of carbohydrate-protein interaction systems as potential therapeutic targets
    [Koichi KATO]
    Institute for Molecular Science and Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, Japan
  4. Systems glycobiology approach for understanding glycan functions in disease
    [Naoyuki TANIGUCHI]
    Systems Glycobiology Research Group, RIKEN Advanced Science Institute and Disease Glycoprobe Team, RIKEN Max Plank Joint Center, Japan
  5. Characterization of the galectin family genes of Caenorhabditis elegans: Carbohydrate-binding properties and phenotypes of mutant worms under stress conditions
    [Yoko NEMOTO-SASAKI]
    Department of Biological Chemistry, Teikyo University School of Pharmaceutical Sciences, Japan
  6. Molecular mechanism of rhamnose-binding lectin-induced early apoptotic status in Gb3-expressing tumor cells
    [Shigeki SUGAWARA]
    Division of Cell Recognition Study, Institute of Molecular Biomembrane and Glycobiology, Tohoku Pharmaceutical University, Japan

SessionE
Molecular interaction in the domain

  1. Membrane functions supported by glycans and glycolipids
    [Akemi SUZUKI]
    Institute of Glycoscience, Tokai University, Japan
  2. Regulatory mechanisms of malignant phenotypes of humancancers by tumor-associated carbohydrate antigens in the microdomains
    [Koichi FURUKAWA]
    Department of Biochemistry II, Nagoya University Graduate School of Medicine, Japan
  3. Regulation of mammalian glycosylation enzyme expression during human stem cell differentiation
    [Kelley W. MOREMEN]
    Complex Carbohydrate Research Center, University of Georgia, USA
  4. Human-specific evolution of siglecs
    [Ajit VARKI]
    Glycobiology Research and Training Center, University of California-San Diego, USA

SessionF
Glycobiology and beyond

  1. Trans to cis
    [Akemi SUZUKI]
    Institute of Glycoscience, Tokai University, Japan
  2. From snapshots to movies
    [Naoyuki TANIGUCHI]
    Systems Glycobiology Research Group, RIKEN Advanced Science Institute and Disease Glycoprobe Team, RIKEN Max Plank Joint Center, Japan
  3. Carbohydrate-based drug discovery and vaccine development
    [Chi-HueyWONG]
    Academia Sinica, Taiwan
  4. Glycosylation of lysosomal lipid binding proteins is essential for their function
    [Konrad SANDHOFF]
    LIMES c/o Kekulé-Institut, University of Bonn, Germany
  5. Thoughts on the future of glycosciences
    [Ajit VARKI]
    Glycobiology Research and Training Center, University of California-San Diego, USA